What is the difference between “Lozap” and “Lozap plus”: comparison of compositions, indications for use and contraindications

Due to regular increases in blood pressure, serious heart and vascular diseases occur. This situation is typical not only for older people, but also for young people. It is unlikely that it will be possible to completely get rid of the disease, but by using certain medications, as well as monitoring blood pressure, it is possible to minimize complications.

Medicinal medications whose action is aimed at lowering, controlling and maintaining normal blood pressure levels (hereinafter referred to as BP) include “Lozap” and “Lozap plus”.

Medicines can reduce the load on the heart and have a moderate diuretic effect. But these medications are slightly different, so a comparison between Lozapa and Lozapa Plus is necessary.

The drugs described differ in many respects, which include active ingredients, dosage, instructions for use.

general description

Is as follows:

Characteristics of Lozap

The drug, which is an angiotensin receptor blocker, is available in the form of elongated, biconvex, white, film-coated tablets, each of which may contain the active ingredient losartan potassium in the following concentrations:

• 12.5 mg;
• 50 mg;
• 100 mg.

Lozap and Lozap Plus are able to reduce both blood pressure and pressure in the pulmonary circulation.

The medicine is sold in cardboard packs of 30, 60 or 90 tablets.

Losartan potassium, the active component of Lozap, can have the following effects on the body:

• selectively block the action of angiotensin II;
• increase renin activity;
• inhibit aldosterone, thereby reducing potassium losses caused by taking a diuretic;
• normalize the urea content in plasma.

In patients with arterial hypertension not complicated by diabetes mellitus, therapy with this drug can reduce the manifestations of proteinuria.

Patients with chronic heart failure are advised to take the drug prophylactically.

Patients with chronic heart failure are advised to take prophylactic measures to:

• increasing tolerance to physical activity;
• preventing myocardial hypertrophy.

Indications for the use of Lozap are the following conditions:

1. Arterial hypertension.
2. Chronic heart failure.
3. The need to reduce the risk of cardiovascular disease.

The dosage should be adjusted downward when:

• liver diseases;
• dehydration;
• carrying out hemodialysis;
• The patient is over 75 years old.

The drug is contraindicated in pregnant and lactating women, as well as persons under 18 years of age. Its use is not recommended in case of hypersensitivity to the active or auxiliary components.

When prescribing, caution should be exercised if the patient has:

• heart failure;
• IHD;
• cerebrovascular diseases;
• stenosis of the renal arteries, or the aortic and mitral valves;
• water-electrolyte imbalance;
• history of angioedema.

Allergy is one of the side effects of taking the drug.

Taking losartan potassium can cause a number of negative reactions. Among them:

• anemia and other deterioration of the circulatory and lymphatic systems;
• manifestations of allergies;
• gout;
• anorexia;
• insomnia or sleep disturbances;
• anxiety and other mental disorders;
• headaches and other manifestations of nervous system disorders;
• decreased visual acuity, conjunctivitis;
• angina pectoris, heart rhythm disturbances, heart attack, stroke and other disorders of the cardiovascular system;
• cough, runny nose;
• abdominal pain, nausea, diarrhea and other gastrointestinal reactions;
• myalgia;
• liver and/or kidney dysfunction;
• swelling;
• asthenia, chronic fatigue syndrome.

Compound

The described drugs are based on one active substance – losartan. Lozap Plus contains the addition of hydrochlorothiazide, which complements and enhances the effect of the first.

The main substance helps in reducing blood pressure to normal and protects the heart from stress. The additional component has a diuretic effect, increasing the effectiveness of the main ingredient. “Lozap plus” stands out because it has a stronger hypotensive effect.

Comparison of Lozapa and Lozapa Plus

Similarities

The drugs under consideration share the following features:

• indications for use;
• tablet form of the drug;
• the presence of potassium losartan in the composition.

What is the difference?

The main distinguishing feature is the difference in composition. Lozap is a single drug, and Lozap Plus is a combined medication containing 2 active ingredients.

The second significant difference is that Lozap has different dosages, while the combination medicine is available in only 1 version.

Which is cheaper?

You can purchase a pack of 30 tablets of these medications at the following prices:

• 50 mg - 246 rubles;
• 50 mg + 12.5 mg - 306 rub.

At the same concentration of losartan potassium, a drug containing hydrochlorothiazide is 25% more expensive.

Lozap is considered a safe remedy for reducing blood pressure in diabetes mellitus.

For what diseases is it taken?

The described medications should be taken when:

• hypertension;
• diabetic nephropathy;
• chronic heart failure.

And also in order to reduce the likelihood of developing cardiovascular diseases and reduce mortality in people with hypertrophy and hypertension of the left ventricle of the heart.

In addition to the indications described, taking Lozapa Plus is recommended for conditions where additional diuretic therapy is required. The drug can be used by elderly people. In a situation where other ACE inhibitors are not suitable, Lozap Plus can also be prescribed.

Therapeutic properties

Indications for the use of the drug "Lozap" are different. The drug will allow:

1. Reduce blood pressure and keep it normal.
2. Reduce the load on the heart.
3. Reduce the amount of aldosterone and adrenaline in the blood.
4. Increase tolerance to physical and emotional stress in people with cardiovascular diseases.
5. Improve cardiac circulation and renal blood flow intensity.

A moderate diuretic effect is also possible from taking the drug.

Within a few hours you can notice the first positive effect from taking the capsule. It will keep throughout the day. For a sustained reduction in blood pressure, the therapeutic course should be 1 month.

The drug is particularly effective in treating those with malignant arterial hypertension.

“Lozap Plus”, in addition to the described therapeutic actions, produces additional:

1. Helps reduce the concentration of potassium in the blood.
2. Activates the production of the hormone renin.
3. Reduces the concentration of uric acid and accelerates its elimination.

The active substances of the drugs are perfectly absorbed by the body and quickly enter the bloodstream from the gastrointestinal tract.

Video on the topic

About the features of treating hypertension with Lozap in the video:

The doctor will help the patient decide which of the 2 varieties of Lozap is better in each individual case. The main difference between the medications is the more pronounced hypotensive effect of Lozap plus tablets. Many consider it more convenient to use, because if combination therapy is prescribed, you will not have to drink an additional diuretic.

It is already contained in the drug. The cost of the medicines also differs: Lozap costs 2 times less than Lozap plus. Despite the fact that both drugs belong to the same drug group and have approximately the same effect, you should not replace one drug with another on your own.

The information on the MyMedNews.ru website is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment.

MyMedNews.ru

And we also have

• Comparison of Betaloc ZOK or Concor: which is better and how do they differ?

Recommended dosages, features

Not everyone knows how “Lozap” differs from “Lozap plus”. Prescribe medications once a day at the same time, preferably in the morning. The tablet should not be crushed or crushed. It must be swallowed whole and washed down with half a glass of water. Taking capsules is not associated with eating food.

The duration of the therapeutic course is determined by the doctor, taking into account a number of parameters: the patient’s condition and the effectiveness of treatment. As a rule, the drug is taken for a long time, up to several years.

Considering how “Lozap” differs from “Lozap plus”, it is worth giving the recommended dosages for the first:

1. High blood pressure: 50 mg once a day for a long time. If the doctor considers it necessary, the dosage is increased to 100 mg. Tablets are either taken once a day or divided into 2 doses.
2. Chronic heart failure: 12.5 mg per day, course 7 days. Gradually this dose is doubled and taken for another week. The effectiveness of the drug is assessed. If the required effectiveness has not been achieved, then the dosage is increased to 50 mg. The doctor may increase the dosage to 100 mg. Exceeding the specified dosages is unacceptable. If taking the maximum dose does not provide the required effectiveness, then another medication is selected.
3. Diabetes mellitus and hypertension: 50 mg per day. After 1-2 weeks, the dosage is increased to 100 mg per day.
4. Prevention of cardiovascular disease and mortality: 50 mg. After 2-3 weeks, the effectiveness of therapy will be determined. If it turns out to be insufficient, then you should continue to take 50 mg of the drug for a long period of time.
5. Taking diuretics in high doses simultaneously with the drug: daily dose 25 mg.

Elderly people also adhere to the indicated dosages without reducing them. Those over 75 years of age and with liver and kidney disease should take 25 mg once a day. For them, a maximum of 50 mg is allowed at a time.

Dosage instructions for Lozapa Plus:

1. High blood pressure: 1 pill once a day. After 21-35 days, therapy is assessed. If blood pressure returns to normal, then continue taking the same dosage. If not, then increase the number of tablets at a time to 2 units.
2. Prevention of mortality and development of heart and vascular diseases: 1 tablet once a day. If after 3-5 weeks the required result is not obtained from treatment, then 2 capsules are prescribed.

The maximum daily dose of Lozapa Plus is two tablets.

Characteristics of Lozap Plus

A combined drug produced in the form of elongated yellow film-coated tablets with a separation line on both sides. It contains 2 active ingredients:

• angiotensin II potassium receptor antagonist losartan - 50 mg;
• diuretic hydrochlorothiazide - 12.5 mg.

Lozap Plus is a combined drug produced in the form of elongated yellow film-coated tablets with a separation line on both sides.

Blisters containing 10 or 15 tablets are packaged in cardboard packs of 1, 2, 3, 4, 6 or 9 pieces.

The pharmacological action of hydrochlorothiazide is to increase:

• aldosterone production;
• plasma angiotensin II concentrations;
• renin activity.

In addition, its use reduces the volume of blood plasma and the amount of potassium in it.

Taking this substance together with losartan potassium provides:

• synergistic effect, due to which a more pronounced hypotensive effect is achieved;
• weakening of hyperuricemia initiated by a diuretic.

It is important that treatment with this medication does not cause changes in heart rate. The drug is indicated for use in arterial hypertension requiring combination therapy. In addition, its use can reduce the risk of developing cardiovascular diseases due to arterial hypertension and left ventricular hypertrophy.

Lozap Plus is not prescribed for gout.

The initial dosage of the drug is 1 tablet per day. If necessary, it can be doubled, while the dose is still carried out once. The daily dose should be adjusted in the presence of the same number of indications as for the single drug Lozap.

The drug is not prescribed for:

• hyper- or hypokalemia, hyponatremia;
• severe diseases of the kidneys, liver or biliary tract;
• gout or hyperuricemia;
• anuria;
• pregnancy, lactation, and also during the period of planning conception;
• hypersensitivity to the components of the drug or sulfonamide derivatives.

It should be used with caution in the same conditions as the single drug Lozap, as well as in:

• hypomagnesemia;
• connective tissue diseases;
• diabetes mellitus;
• myopia;
• bronchial asthma;

No side effects of the drug associated with the combined use of losartan with hydrochlorothiazide were identified. All negative effects that occur during such therapy are due to the influence of each substance separately.

For bronchial asthma, the drug should be used with caution.

In addition to the side effects caused by losartan potassium and identical to the negative reactions that occur when taking Lozap, Lozap Plus can cause:

• vasculitis;
• respiratory distress syndrome;
• jaundice and cholecystitis;
• convulsions.

List of contraindications

It is difficult for an ordinary person to say how “Lozap” differs from “Lozap plus”. The medications in question are not intended for children. As a rule, they are prescribed to those who are over 18 years old. Women carrying a child and those who are breastfeeding are contraindicated in taking the drug. In case of individual intolerance to the main substances of the drugs, their use is contraindicated.

Taking Lozapa Plus is prohibited for bilateral renal artery stenosis. Anuria and hypovolemia are also conditions in which taking medications is undesirable.

Reviews about the drugs

Among those who take both medications, many note that they reduce blood pressure well. But some have noticed that Lozap Plus helps them better.

Such patients say that it lasts a little longer and reduces blood pressure faster. The majority of patients approve of the fact that both drugs can be taken regardless of food intake, and also that they take the medicine only once a day.

Among the advantages of both drugs is that they do not cause allergic reactions. But patients like LP because it does not require additional diuretics. Negative reviews are mainly due to the fact that Lozap plus costs about twice as much as the regular drug. At the same time, they note that it is more profitable to buy large packages of medicines.

Side effects and overdose

As a rule, when taking Lozapa Plus and Lozapa, the contraindications and side effects are minor. However, in case of an overdose the following reactions may occur:

• insomnia;
• gastrointestinal disorders;
• cough;
• respiratory congestion;
• swelling;
• pain in the abdominal area;
• cramping syndrome in the legs;
• rapid pulse;
• asthenia;
• hypotension;
• tachycardia;
• bradycardia.

If such symptoms appear, stop taking the drug.

Combination with other drugs

Interaction with other antihypertensive medications leads to an enhanced therapeutic effect. “Lozap” and “Lozap plus” can be combined with other drugs for the treatment of hypertension and heart failure.

Taking Lozapa Plus together with potassium-sparing diuretics is undesirable, as hyperkalemia may occur.

Not everyone knows the difference between Lozap and Lozapa Plus. Both described drugs are prohibited from being combined with alcohol, since such a combination can lead to a decrease in blood pressure. In this case, the person will experience nausea, vomiting, dizziness, numbness of the limbs, and impaired coordination of movements. He may feel generally unwell.

If taking Lozapa Plus is combined with drinking alcoholic beverages, you may notice a decrease in the therapeutic effect of the drug. It contains a diuretic component. When combined with alcohol, urination increases, and accordingly, the concentration of the active substance decreases.

If the patient has previously had angioedema, then throughout the entire therapy with the described drugs, medical supervision should be exercised, since a relapse of a severe allergic reaction is possible.

If a patient is diagnosed with hypovolemia or hyponatremia, caused by various factors, then hypotension may develop when taking Lozap and Lozap plus. If these disorders are present, before starting therapy with the described drugs, it is necessary to eliminate disturbances in the water-electrolyte balance or take both drugs in minimal dosages.

What is better Lozap or Lozap Plus?

The decision about which medicine will be best for the patient can only be made by a doctor after collecting an anamnesis and conducting an examination. The advantage of Lozap Plus will be its more pronounced therapeutic effect. The advantage of Lozap is the ease of selecting the dosage. In addition, the single drug causes fewer negative reactions and has fewer contraindications.

For diabetes

The active component of Lozapa Losartan in a dose of up to 150 mg/day does not affect the concentration of sugar in the blood. The great advantage of this substance for those who suffer from type 2 diabetes is its ability to reduce insulin resistance. Therefore, Lozap is considered a safe remedy for reducing blood pressure in this disease.

Thiazide diuretics, which include hydrochlorothiazide, may increase glucose levels. For diabetic patients, such substances should be prescribed in minimal doses (no more than 25 mg/day). In addition, you need to know that if you have high blood sugar, the combination of Lozap Plus with aliskiren is unacceptable. Therefore, in case of such a disease, this drug should be taken with caution.

Advantages and disadvantages

It is difficult to determine which is better - “Lozap” or “Lozap plus”. People who have been prescribed these medications note that they effectively lower blood pressure. For some, Lozap Plus helped more effectively, as it lowers blood pressure faster.

The advantages of “Lozapa” and “Lozapa plus”, according to reviews of cardiologists, are as follows:

1. The drugs are taken only once a day, and there is no connection with food intake.
2. “Lozap” and “Lozap plus” do not lead to allergies.
3. When stopping treatment with drugs, there is no so-called withdrawal syndrome.
4. When taking Lozap Plus, you do not need to take additional diuretics.

Disadvantages: cost. Since Lozapa Plus contains 2 components, its price is 2 times higher than Lozapa.

Reviews from doctors

Sorokin V.T., therapist, 32 years old: “I prescribe drugs of this group for hypertension in the initial stage. I consider these products to be quite safe for the body and effective in reducing blood pressure. “I would like to note that in severe stages of the disease, the effect of these medications will not be enough for a day and you should use another type of antihypertensive drugs, for example, beta blockers.”

Dorogina M.N., cardiologist, 43 years old: “During my practice, I came to the conclusion that the Slovak Lozap is better tolerated than its Russian counterparts. More than 90% of patients noted normalization of blood pressure and the absence of adverse reactions.