Veins are blood vessels that carry blood to the heart. In turn, blood is collected in the veins from capillaries. With healthy arteries, the circulatory system works stably. But what happens if problems arise with the veins? Swelling, pain in the legs, slight numbness, goosebumps, heaviness, impaired sensitivity in the form of paresthesia, convulsions, trophic disorders. These signs, repeated day after day, are most likely recognized by the doctor as venous insufficiency.
Excess body weight can lead to varicose veins
Pharmacodynamics, pharmacokinetics
The medicine has a venotonic, angioprotective effect. After its use, venostasis, capillary permeability, and vein distensibility decrease.
In addition, taking the medicine helps:
- Improving microcirculation
- Lymphatic drainage
- Increased tone of venous walls
- Reducing the interaction of leukocytes and endothelium
Basically, active substances are excreted through the intestines, a small part of them through the kidneys.
Analogues of the drug Detralex
For problems with veins and varicose veins, it is possible to use Detralex analogues. They can have a similar therapeutic effect, but have their own contraindications, dosages and possible side effects. Be sure to consult a specialist!
So the pharmaceutical market offers us the following analogues of Detralex:
Venozol
The main active ingredients, like Detralex, are diosmin and hesperidin. Pharmacological action is similar to Detralex. Release form: tablets, gel and cream.
Vasocket
The active substance (diosmin) reduces the distensibility and increases the tone of the veins, thereby preventing the appearance of edema. Available in tablet form.
Antistax
Bioflavonoid drug belongs to the group of venotonic drugs. Available in tablet form.
Troxevasin
Produced under the trade names Venoruton, Troxerutin. Improves the condition of the walls of blood vessels and has an anti-edematous effect. Main forms of release: capsules, gel for topical use, solution for injection in ampoules.
Analogues of the drug Detralex
Anavenol
Combined venoprotective drug. Available in tablet form. Side effects: bleeding, dizziness, nausea. Contraindicated for children under 15 years of age.
Venoruton
Angioprotective drug. The active ingredient is hydroxyethylrutoside. Release form: tablets and gel for external use. Possible use in the second and third trimesters of pregnancy.
Ginkor fort
Venotonic and venoprotective drug It contains a standardized extract of ginkgo biloba, heptaminol hydrochloride and troxerutin. Available in the form of capsules and gel for external use. In case of overdose, blood pressure may increase. According to indications, the drug can be prescribed in the second and third trimesters of pregnancy. Contraindicated in hyperthyroidism and concomitant use of MAO inhibitors.
Detralex or Venarus?
Venarus is a generic drug. That is, it is based on the same active ingredients (diosmin and hesperidin), but the original drug (Detralex) always contains components of a higher degree of purification. Therefore, its effectiveness is higher and its tolerability is better. In addition, Venarus is characterized by lower bioavailability and more often provokes adverse reactions in the body. The drug is also contraindicated during lactation. The pharmacological action is similar to the drug Detralex. There is no fundamental difference between them. Recommendations for taking medications for varicose veins and hemorrhoids are identical.
Detralex or Phlebodia?
The active ingredient of the drug Phlebodia 600 is diosmin. But its concentration in Detralex is 450 mg/tablet (plus its enhancing hesperidin 50 mg/tablet), and Phlebodia 600 is available in the form of tablets with a diosmin concentration of 600 mg/tablet.
The medicine has a therapeutic effect similar to Detralex. It also increases the tone of the venous wall, improves blood flow, and normalizes the permeability of vascular walls.
Nevertheless, Detralex is absorbed into the body faster than its analogue, and its concentration in the blood plasma reaches its maximum after three to four hours.
In what cases are Detralex tablets prescribed?
The use of Detralex is advisable for venolymphatic insufficiency of the legs, in which the following occurs:
- pain and swelling
- heaviness in the legs
- convulsive manifestations
- trophic disorders
The pharmaceutical agent is prescribed for the treatment of acute hemorrhoidal attack.
Important to know: Detralex for hemorrhoids and varicose veins is used as a symptomatic drug, most often used as a complex treatment.
Side effects
When taking the drug Detralex, in rare cases, the following adverse reactions may develop:
- from the gastrointestinal tract: dyspepsia, diarrhea, nausea, vomiting, colitis;
- from the central nervous system: headache, dizziness, general malaise;
- from the skin: urticaria, itching, rash, isolated swelling of the face, eyelids, lips, angioedema.
If any side effects occur, you should consult your doctor and adjust your treatment.
Detralex, how much to drink
It is wise to take Detralex only as prescribed by a doctor; self-medication can lead to undesirable consequences. Based on the complexity of the situation and the course of the disease, the doctor must determine the duration of the therapeutic course. It is useful to know that even taking several tablets can lead to drug addiction.
If necessary, the doctor may prescribe a second course of medication.
For chronic hemorrhoids, tablets are usually taken for 2-3 months.
Medicine Detralex
Detralex is produced by the French company Servier, whose production complex is located, among other things, in Russia.
The main principle of the company producing Detralex is environmental friendliness, naturalness and safety. Therefore, all Servier products are a guarantee of high quality. Detralex is no exception. THIS IS INTERESTING: one of the components of Detralex - hesperidin - is extracted from the peel of unripe oranges. Moreover, the choice of unripe fruits is approached with special care - their size should not exceed 2.5 cm in diameter. Because the smaller the fruit, the more valuable substances it contains. The main countries for orange production are Mexico, Egypt, China and Morocco. First, the orange peels are dried and crushed. This is how the basis for Detralex is obtained - a complex of flavonoids or a flavonoid fraction, which is then sent for refinement and production of the drug we are familiar with.
Instructions for use
For varicose veins, the doctor may prescribe 2 tablets per day. The medicine should be taken one at a time, during lunch and dinner.
In the acute stage of hemorrhoids, doctors prescribe 6 tons of tablets per day in the first 4 days of treatment, and in the next 3 days you need to drink 4 tablets every day. The daily dosage must be divided into several doses; the medication should be taken during meals. After taking the medicine for a week, the dose is reduced by 2 times, taken only once a day.
Composition of Detralex
The main active ingredients of Detralex are diosmin 900 mg (90%) and hesperidin 100 mg (10%). As well as excipients to ensure better absorption of active substances and their transportation to their destination, that is, to the vascular system. Both active ingredients of Detralex are flavonoids, which are obtained from orange peel. Detralex is a semi-synthetic drug with proven effectiveness and numerous clinical studies.
An important component in the production of Detralex is the process of micronization (grinding) of the active substance. This is an expensive stage of production. Few enterprises include it in the drug manufacturing cycle. But it is this procedure that minimizes the effect of the drug on the gastrointestinal tract and promotes good bioavailability, that is, absorption in the body. Thus, the good tolerability of Detralex is one of its main advantages over other phlebotonics.
Release form and dosage of Detralex
Detralex tablets
The tablet form of the drug Detralek is available in dosages of 500 mg and 1000 mg.
The number of tablets in packages is 30 and 60 pcs. For the treatment and prevention of varicose veins for 1 month and 3 months, respectively (1 tablet 1 time per day). The drug is also available in a package of 18 tablets at a dosage of 1000 mg - for the treatment of hemorrhoids. Detralex suspension
Detralex suspension is ready for use, easy to swallow, does not require dilution or washing down with water - you just need to squeeze the suspension from the bag directly into your mouth/spoon and swallow. This form is perfect for people leading an active lifestyle, for those who are often on the road and flying. 1 sachet contains 1000 mg of active ingredient. There are 30 sachets in one package.
Detragel
Detralex gel (Detragel) for topical use in complex therapy for the treatment and prevention of varicose veins. As an independent remedy, it can be used for fatigue and heaviness in the legs, as well as pain, swelling, contusions and bruises. Does not leave marks on clothes and skin. In the production of the gel, an innovative substance delivery system is used, due to which the active substances quickly penetrate the body. Can be used either alone or in combination with the venotonic Detralex in the form of tablets or suspension. Available in volumes of 40 mg and 80 mg.
Indications for Detralex
The drug Detralex is indicated for eliminating and alleviating the symptoms of venous diseases of varying severity. A course of Detralex eliminates the symptoms of venous-lymphatic insufficiency:
- pain and discomfort in the limbs;
- cramps in the legs and feet;
- feeling of heaviness and fullness;
- "tired" legs.
It also effectively fights the visible manifestations of venous-lymphatic insufficiency:
- swelling;
- trophic changes in the skin and subcutaneous tissue;
- venous trophic ulcers.
- spider veins
Treatment of varicose veins
Regimen for taking Detralex for varicose veins
In order to prevent swelling and heaviness, varicose veins and venous insufficiency, if there is a risk (sedentary/standing work, increased stress), the recommended dose is 1 tablet per day for 3-6 months. After a break, the course of the drug can be repeated. Monotherapy using only detragel is also suitable as a preventive measure.
Treatment of hemorrhoids
Hemorrhoids are the result of impaired blood circulation and an inflammatory process in the choroid plexus of the rectum, which is accompanied by thrombosis, varicose veins, as well as sclerosis of the veins with frequent complications in the form of bleeding and pain during defecation. Detralex for hemorrhoids is prescribed in a short course, lasting 7 days.
Dosage regimen for hemorrhoids
Contraindications
The drug Detralex has one main contraindication - individual intolerance to the active substances and components of the drug. In rare cases, during clinical studies, side effects such as nausea, vomiting and stool upset, allergic reactions in the form of urticaria and itching were observed (therefore, persons with a tendency to allergies of various origins should take the drug with caution), headaches and weakness.
Before you start taking Detralex orally, you should notify your doctor about all the existing characteristics of your body in order to draw up the most successful treatment regimen with Detralex.
Can Detralex be used by pregnant women?
In the first trimester of pregnancy, the medicine can be prescribed only in exceptional cases when the risk of blood clots is high.
In other situations, according to the doctor’s decision, the drug is prescribed after the 20th week of pregnancy.
Detralex is also prescribed to pregnant women for hemorrhoids and varicose veins; it helps cope well with swelling of the legs.
Obstetricians and gynecologists are of the opinion that the drug does not have a negative effect on the body of the woman and the fetus. Therefore, if necessary, they consider it advisable to use it.
Detrolex reduces the risk of developing thrombophlebitis or exacerbation of hemorrhoids in pregnant women.
Chronic venous insufficiency
Chronic venous insufficiency is a common peripheral vascular disease that occurs as a result of impaired blood flow through the veins of the lower extremities and changes in the permeability of the vascular wall. Most often, venous insufficiency develops in women. The disease occurs when the valves that close the veins are unable to prevent blood from flowing back due to increased pressure on them. As a result, this leads to stretching of the walls of the venous vessels. The permeability of the vascular wall for blood and plasma proteins increases, swelling and compaction of adjacent tissues appear. Where small vessels are compressed, areas of ischemia (insufficient blood supply with oxygen) occur, which contributes to the formation of trophic ulcers.
The main risk factors for the development of chronic venous insufficiency include:
- weakness of the muscular wall of the veins (hereditary);
- overweight and obesity;
- pregnancy and childbirth;
- long-term constant work in a standing or sitting position, with limited movement (cooks, office workers, surgeons, etc.);
- chronic constipation;
- fluctuations in hormonal levels in women (contraception with hormonal drugs, hormonal treatment during menopause, etc.);
- wearing tight underwear and clothing, corsets.
The following stages of development of varicose veins are distinguished:
- Stage 0 – no major symptoms upon examination.
- Stage I - “morning fatigue” of the legs, complaints of intermittent swelling in the evenings (disappears in the morning).
- Stage II – persistent swelling, skin pigmentation disorders; some areas of the skin become thicker, the skin above them cannot be folded (lipodermatosclerosis), redness appears on the skin, accompanied by itching and weeping (eczema).
- Stage III – the formation of trophic ulcers (active or healed), difficult to treat with medication.
The disease is accompanied by pain of varying intensity and the presence of evening cramps. In the treatment of varicose veins in the early stages, compression with elastic bandages and compression hosiery, physiotherapy and therapy in a sanatorium are used.
Interaction
No special studies have been conducted to identify the interaction of Detralex with other drugs. However, to date there are no reports of negative interactions between the drugs and other medications.
Special studies regarding drug and other forms of drug interaction have not been conducted. However, given the extensive experience of post-registration use of Detralex, to date there are no statements about its adverse interaction with other drugs.
Detralex during pregnancy and lactation
Detralex is not recommended for pregnant women
The use of Detralex by pregnant women and children during breastfeeding is not recommended due to insufficient research and clinical data. There is no information on the occurrence of side effects in pregnant women, nor has there been any information recorded on the ability of the active ingredients - diosmin and hesperidin - to pass into breast milk during breastfeeding, as well as in children during breastfeeding.
special instructions
During treatment with Detralex, some of its features should be taken into account. This will help prevent complications and achieve the desired result of therapy.
Use during pregnancy and lactation
The use of the medicine is contraindicated in the first 3 months of pregnancy and during breastfeeding, since there is insufficient information about its safety during this period. If necessary, the doctor can prescribe pills to women in the second and third trimester of pregnancy. The duration of use and dose of Detralex during pregnancy are determined taking into account the mother’s well-being and the diagnosis.
Detrilex is contraindicated in the first trimester of pregnancy; in the subsequent period it is prescribed with great caution
Children
The drug is prohibited for use among children. There is no information about its effect on the child’s body and the possibility of developing side effects. The drug is prescribed to patients over 18 years of age.
Effect on concentration
The medicine does not affect the speed of mental and physical reactions, it is allowed among groomsmen and people whose work activities require increased concentration.
Combination with other drugs
According to the study, Detralex does not affect the action of drugs from other drug groups, but treating the disease with the help of the drug is allowed in combination with other drugs as prescribed by a specialist.
Interaction with alcohol
There was no direct interaction between alcoholic beverages and the action of Detralex, but it has been proven that alcohol has a detrimental effect on the course of hemorrhoids. Therefore, the combination of a disease and taking medications to treat it is considered unacceptable.
Note!
The description of the drug Detralex on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Detralex: indications for use
Detralex is prescribed to alleviate and eliminate the symptoms of diseases in which the tone of blood vessels is impaired:
- varicose veins, accompanied by pain, which is caused by cramps in the lower extremities that occur at night, a feeling of “fatigue, fullness, stiffness in the morning, heaviness and swelling” in the legs.
- to alleviate acute and chronic hemorrhoids.
For the treatment of chronic venous insufficiency of the lower extremities, which impedes the outflow of lymph:
- with trophic changes in the skin
- trophic ulcers of veins
- swelling in the lower extremities.
Reviews
Reviews about the drug for hemorrhoids are predominantly positive. Most patients note an improvement in their well-being, a decrease in itching, burning, discomfort and other unpleasant symptoms within 5–7 days after using the drug. Sometimes an allergic reaction occurs in the form of urticaria, itching or disorders of the digestive system. Such phenomena indicate the presence of an allergy to one or another component of the product. Negative signs often go away on their own after stopping the medication.
Svetlana “My doctor prescribed Detralex for me as a complex therapy for hemorrhoids. I have been suffering from the disease for several years; varicose veins of the rectum appeared after childbirth. I can only say positive things about the drug. The therapeutic effect occurred within a week of using the product. After completing the course of treatment I feel significant relief.”
Mikhail “The doctor diagnosed me with external hemorrhoids. I was treated with various ointments for a long time, but the effect was temporary. I learned about Detralex from a friend, after consulting with a specialist, I decided to try the drug in action. I was more than satisfied with the result. After just a few days, the symptoms of hemorrhoids decreased significantly, the doctor noted an improvement in the condition of the veins. I recommend the medicine to everyone."
Antonina “I have been using Detralex for a long time. The drug does not cause side effects, eliminates signs of hemorrhoids well, strengthens blood vessels, and prevents complications. I take pills during an exacerbation or for prevention for a course of 30 days once a year. I recommend Detralex to everyone as an effective and safe remedy.”
Composition of the drug
The use of Detralex for hemorrhoids provides a positive result due to its uniquely selected composition. The active components of the drug are the following components:
- Diosmin;
- Hesperidin;
- magnesium stearate;
- gelatin;
- glycerol;
- hypromellose;
- titanium dioxide and others.
Diosmin is the main active ingredient that has a tonic effect on capillaries and blood vessels. Thanks to it, the walls of veins are strengthened, their permeability decreases, and elasticity increases. Diosmin prevents stagnation, strengthens the walls of blood vessels, and increases local immunity. The component undergoes a unique treatment (micronization), which allows it to be absorbed into the blood faster. Thanks to this, the effect of the drug occurs faster than when using similar products.
Hesperidin has an equally important effect. It is a flavonoid that helps enhance the effects of Diosmin. In addition, the component prevents the adhesion of leukocytes to the endothelial wall, thereby reducing the negative impact of substances synthesized during the inflammatory process on the valve flaps of blood vessels and veins.
