Treatment of hemorrhoids in the first stages is possible with conservative therapy. The treatment regimen includes numerous groups of internal and local drugs, which together help get rid of the pathology.
Phlebodia for hemorrhoids refers to venotonic drugs that reduce congestion in the venous vessels, tones them, and also helps improve microcirculation and increase capillary resistance.
The drug has a pronounced positive effect and is very often part of the complex treatment of hemorrhoids.
pharmachologic effect
Venotonic effect: reduces the distensibility of veins, increases the tone of veins, reduces venous congestion, enhances the vasoconstrictor effect of adrenaline, norepinephrine. One tablet contains 600 mg of diosmin, which is the optimal daily dose for the venotonic effect.
Angioprotective effect: improves microcirculation; increases capillary resistance; reduces their permeability.
Effect on the lymphatic system: improves lymphatic drainage, increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure.
Has an anti-edematous effect. Reduces symptoms of inflammation (dose-dependent effect).
Reduces the adhesion of leukocytes to the venous wall and their migration into paravasal tissues; improves oxygen diffusion and perfusion in tissue. Blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.
A decrease in mean venous pressure in the system of superficial and deep veins of the lower extremities was confirmed, demonstrated in a double-blind, placebo-controlled study conducted under Doppler ultrasound control; as well as increased systolic and diastolic blood pressure in patients with postoperative orthostatic hypotension.
Release form and composition
Phlebodia 600 is in tablet form. One blister contains 15 round, pink, film-coated tablets with a grey-brown center. Available options allow up to 2 records to be included in the package.
Diosmin (600 mg) is the main active substance, the properties of which provide the drug with a therapeutic effect. The component has the following effects:
- tones venous vessels;
- stimulates blood circulation;
- reduces and prevents venous stagnation;
- improves blood supply to tissues;
- helps normalize lymph outflow;
- increases the resistance of capillaries to various factors;
- prevents excessive vascular permeability;
- has a vasoconstrictor effect;
- eliminates and prevents inflammatory processes;
- eliminates pain and swelling;
- helps improve lymphatic drainage.
Phlebodia contains:
- microcrystalline cellulose (910 mg);
- talc (10.24 mg);
- colloidal silicon dioxide (3.5 mg);
- stearic acid (50.05 mg);
- opaglos 6000 (beeswax and palm wax, 95% ethanol, gummilak)
The shell is formed by: hypromellose, microcrystalline cellulose, polyethylene glycol stearate 400.
This is what Phlebodia tablets look like
Pharmacokinetics
Suction and distribution
After oral administration, it is quickly absorbed from the gastrointestinal tract and is found in plasma 2 hours after administration. Cmax in blood plasma is achieved 15 hours after administration.
It is evenly distributed and accumulates in all layers of the wall of the vena cava and saphenous veins of the lower extremities, to a lesser extent in the kidneys, liver and lungs and other tissues.
Selective accumulation of diosmin and/or its metabolites in venous vessels reaches a maximum at 9 hours after administration and persists for 96 hours.
Removal
It is excreted mainly by the kidneys - 79%, as well as by the intestines - 11%, with bile - 2.4%.
Treatment regimen
In the complex treatment of hemorrhoids, the use of Phlebodia is accompanied by:
- anticoagulants, which help eliminate bleeding, blood clots, swelling, and have an anti-inflammatory effect (Heparin ointment);
- hemostatics, coagulants, preventing and eliminating bleeding (Natalsid);
- antispasmodics that relieve pain and eliminate spasms of smooth muscles (belladonna extract);
- immunostimulants – strengthen the body’s immune forces, thereby increasing its resistance to negative factors (Posterizan);
- anesthetics that relieve pain and itching (Lidocaine, Benzocaine);
- antimicrobial drugs that prevent the development of infections and eliminate them (Ethazol sodium, Triclosan);
- anti-inflammatory drugs that promote tissue regeneration and reduce swelling and itching (Bufexamac, Hydrocortisone).
In the treatment of hemorrhoids, Phlebodia is used in parallel with other drugs
How to take Phlebodia is written in detail in the instructions for use. In addition, the proctologist is obliged to provide the patient with all the necessary information about the use of the drug.
In the acute form of hemorrhoids or in case of thrombosis of hemorrhoids, it is recommended to drink the product with meals, 1 tablet three times a day for a week. As acute symptoms resolve, the dosage is reduced to 1 tablet per day for 1–2 months.
For chronic hemorrhoids or taking it as a preventive measure, it is recommended: 1 tablet per day for 2 months with meals.
A positive effect when using Phlebodia should be observed within two weeks after the start of therapy. Otherwise, you need to consult a doctor to change the treatment regimen or undergo additional examination, since the clinical picture of the disease has similar symptoms to serious diseases (anal fissure, polyps, rectal cancer, etc.).
Achieving a lasting positive result is possible with a long course of treatment for Phlebodia.
Do not forget that the effectiveness of hemorrhoid treatment largely depends on patients’ compliance with the following rules:
- diet: excluding spicy, fried and other foods that cause constipation from the diet;
- giving up bad habits (smoking, drinking alcohol);
- normalization of work and rest regimes;
- moderate exercise.
Dosage regimen
The drug is intended for oral administration.
For chronic lymphovenous insufficiency
Prescribe 1 tablet/day in the morning, preferably before meals. The duration of therapy is usually 2 months.
For acute hemorrhoids and exacerbation of chronic hemorrhoids
the drug is prescribed in the first 4 days, 1 tablet. 3 times/day, during meals; in the next 3 days - 1 tablet. 2 times/day, during meals. If symptoms recur, the course of treatment can be repeated as recommended by your doctor.
For chronic hemorrhoids after relief of acute phenomena
It is recommended to continue taking the drug 1 tablet. 1 time/day for 1-2 months.
If one or more doses of the drug are missed, it is necessary to continue using the drug as usual and at the usual dose.
Before using the drug, the patient should consult a doctor.
Contraindications and side effects
The instructions for use of Phlebodia precisely define the groups of patients for whom the drug is not recommended. The product is not used:
- with hypersensitivity to the active substance of the drug;
- during lactation;
- in the 1st trimester of pregnancy.
Phlebodia is not recommended for children and adolescents
In rare cases, use of the drug may lead to:
- to dyspeptic symptoms in the form of diarrhea, heartburn, nausea or vomiting;
- headaches or dizziness;
- allergic reactions (redness, rashes, itching);
- unpleasant odor from the mouth.
It is possible to eliminate unpleasant manifestations after stopping taking the drug.
Clinical manifestations of a drug overdose, as well as its interaction with other medications, have not been described.
Side effect
The incidence of adverse reactions is presented as follows: very often (>1/10 cases), often (>1/100 and 1/1000 and 1/10000 and
The following adverse reactions have been reported while taking Phlebodia 600.
From the gastrointestinal tract:
rarely - dyspeptic disorders (heartburn, nausea, abdominal pain).
From the side of the central nervous system:
rarely - headache.
If any of the side effects indicated in the instructions are aggravated or any other side effects not specified in the instructions are noted, the patient should inform the doctor.
Therapeutic effect
Reviews of Phlebodia for hemorrhoids are extremely positive. This is due to the following effects of the drug:
- reduces the fragility and permeability of blood vessels and capillaries, promotes increased tone. Prevents the distensibility of veins;
- normalizes metabolism;
- eliminates congestion in the veins, relieves swelling;
- reduces blood pressure;
- saturates tissues with oxygen;
- relieves inflammation, eliminates pain;
- prevents cellular aging;
- improves lymphatic drainage;
- prevents the effects of free radicals by blocking their production.
Phlebodia 600 for hemorrhoids has a positive effect on the affected vessels of the hemorrhoidal plexuses, with significant relief of the patient’s condition and accelerated recovery.
In addition to the positive effect in the treatment of hemorrhoids, the advantages of the drug include:
- ease of use. Phlebodia is available in the form of tablets for oral use, which allows them to be used regardless of the situation. This property of the drug greatly facilitates the treatment of such a delicate disease as hemorrhoids;
- Phlebodia fights the main cause of the disease – obstructed venous blood flow;
- symptoms after taking the drug disappear in a short period of time, which significantly improves the quality of life;
- the drug suppresses the progression of the disease;
- prevents complications;
- has a small number of contraindications;
- has few side effects that occur quite rarely;
- has an affordable price.
Use during pregnancy and breastfeeding
Pregnancy
The use of the drug during pregnancy is possible only as prescribed by a doctor in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
Experimental studies have not revealed any teratogenic effects on the fetus. Until now, in clinical practice there have been no reports of cases of malformation or fetotoxic effects on the fetus when using the drug in pregnant women.
Breastfeeding period
Due to the lack of data on the excretion of the drug in breast milk, nursing women are not recommended to use the drug.
Indications for use
The use of Phlebodia for hemorrhoids is similar to other medications and should be carried out exclusively as prescribed by a doctor. It is prescribed for hemorrhoidal manifestations and for the treatment of other diseases associated with vascular pathology.
The drug helps eliminate:
- chronic form of hemorrhoids;
- impaired microcirculation;
- increased capillary fragility;
- varicose veins of the lower extremities;
- spider veins;
- pain, swelling, feeling of heaviness in the legs;
- chronic venous and lymphatic insufficiency;
- a sharp drop in systolic and diastolic pressure when a person stands up, caused by weakened vascular tone (orthostatic hypotension) in the postoperative period;
- trophic lesions of the legs.
Phlebodia is actively involved in the fight against thrombophlebitis
Also, the drug facilitates exacerbations and is used as a component of complex treatment.
It is possible to use the drug in the postoperative period after phlebectomy to avoid the risk of bleeding.
Phlebodia helps prevent hemorrhagic complications during the insertion of an intrauterine device.
