I am glad to welcome you all again to my website! For this article, I chose professional reviews from cardiologists about our drug - Panangin. I searched long and painstakingly so that you could simply click on one link and immediately receive all the information you need from the most competent cardiologists in our country.
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special instructions
Due to the fact that the components of the drug are vulnerable to the aggressive environment of gastric juice and pancreatic enzymes, it is recommended to take Panangin simultaneously with food. This will ensure that the acidity of the stomach is reduced, and most of the enzymes will be occupied with the breakdown of fats and proteins contained in food, which will ensure that potassium and magnesium enter the intestinal lumen, from where the substances are absorbed into the blood.
Taking Panangin should be accompanied by regular blood tests so that the doctor can monitor the content of potassium and magnesium in the cells. This will avoid hyperkalemia and other negative consequences of overdose.
Instructions for use of Panangin drugs
Pharmacodynamics:
the most important intracellular cations of potassium (K+) and magnesium (Mg++) play a key role in the functioning of numerous enzymes, in the formation of bonds between macromolecules and intracellular structures and in the mechanism of muscle contractility.
The intra- and extracellular ratio of potassium, calcium, sodium and magnesium ions affects myocardial contractility. Endogenous aspartate acts as a conductor of ions: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cells. Magnesium and potassium aspartates improve myocardial metabolism. Lack of magnesium/potassium predisposes to the development of arterial hypertension, atherosclerosis of the coronary arteries, arrhythmias and metabolic changes in the myocardium. Taking magnesium and potassium aspartates helps compensate for the lack of these electrolytes in food. Pharmacokinetics:
Magnesium
The total supply of magnesium in the body of a person weighing 70 kg is on average 24 g (1000 mmol); more than 60% of magnesium comes from bone tissue and about 40% from skeletal muscle and other tissues. About 1% of the total magnesium reserve in the body is found in the extracellular fluid, mainly in the blood serum. In healthy adults, the content of magnesium in the blood serum is in the range of 0.7-1.10 mmol/l. Magnesium is absorbed from the gastrointestinal tract by active transport. The main regulator of magnesium balance in the body is the kidneys. 3-5% of ionized magnesium is excreted by the kidneys. An increase in urine volume (for example, during loop diuretic therapy) leads to an increase in the excretion of ionized magnesium. If magnesium absorption in the small intestine is reduced, subsequent hypomagnesemia leads to a decrease in its excretion (less than 0.5 mmol/day).
Potassium
The total potassium reserve in the body of a person weighing 70 kg is on average 140 g (3570 mmol). The total potassium reserve is slightly less in women than in men and decreases slightly with age. 2% of the total potassium reserve in the body is located outside the cells, and the remaining 98% is inside the cells. Potassium is absorbed in the gastrointestinal tract. The optimal intake of potassium from food is 3-4 g (75-100 mmol) per day. The main route of potassium excretion is renal (about 90% of potassium is excreted by the kidneys daily). The remaining 10% is excreted through the gastrointestinal tract. Thus, the kidneys are responsible for long-term potassium homeostasis as well as plasma potassium levels. In the short term, blood potassium levels are also regulated by the flow of potassium between the intracellular and extracellular spaces.
Is it possible to combine Panangin and Riboxin?
It is necessary to combine medications with caution, having first consulted with your doctor. Riboxin, in addition to increasing cell metabolism and improving the absorption of drugs and other elements into the heart tissue, also enhances myocardial contraction. Taking them together can have a beneficial effect - potassium and magnesium best penetrate the fibers of the heart muscle. On the other hand, this may require adjustment of the dosage of Panangin to ensure that the required amounts of potassium and magnesium are not exceeded, in order to eliminate hyperkalemia.
Panangin forte 60 pcs. film-coated tablets
pharmachologic effect
Potassium and magnesium preparation.
Composition and release form Panangin forte 60 pcs. film-coated tablets
Tablets - 1 tablet:
- Active ingredients: potassium aspartate 316.00 mg (in the form of potassium aspartate hemihydrate 332.60 mg), magnesium aspartate 280.00 mg (in the form of magnesium aspartate tetrahydrate 350.00 mg);
- Excipients: corn starch 172.20 mg, talc 20.00 mg, magnesium stearate 8.00 mg, potato starch 6.60 mg, povidone KZO 6.60 mg, colloidal silicon dioxide 4.00 mg;
- Tablet shell: talc 7.30 mg, butyl methacrylate copolymer 6.00 mg, titanium dioxide (color index: CI 77891, E171) 5.30 mg, macrogol-6000 1.40 mg.
15 tablets in a blister made of PVC/PVDC and aluminum foil. 2, 4, 6 blisters along with instructions for use are placed in a cardboard box.
Description of the dosage form
Oval, biconvex, film-coated tablets, white or almost white, with a slightly glossy surface, engraved “A83” on one side, almost odorless. On a cross section it is white or almost white in color.
Directions for use and doses
Before use, you should consult your doctor.
Take orally, without chewing and with plenty of water.
Panangin Forte should be taken after meals, because... the acidic environment of the stomach reduces its effectiveness.
Recommended daily dose: 1 tablet 3 times a day. Maximum daily dose: 1 tablet 3 times a day.
Pharmacodynamics
The most important intracellular cations of potassium (K+) and magnesium (Mg++) play a key role in the functioning of numerous enzymes, in the formation of bonds between macromolecules and intracellular structures and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, calcium, sodium and magnesium ions affects myocardial contractility. Endogenous aspartate acts as a conductor of ions: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cell. Magnesium aspartate and potassium aspartate improve myocardial metabolism.
Lack of magnesium/potassium predisposes to the development of arterial hypertension, atherosclerosis of the coronary arteries, arrhythmias and metabolic changes in the myocardium.
Each tablet of the drug Panangin Forte contains 280 mg of magnesium aspartate and 316 mg of potassium aspartate, which is 2 times higher than the content of active ingredients in the drug Panangin, film-coated tablets. The daily dose of the drug Panangin Forte: 1 tablet 3 times a day, corresponds to the daily dose of the drug Panangin: 2 tablets 3 times a day. Taking a single dose of Panangin Forte in the form of one tablet makes treatment more convenient for the patient.
Pharmacokinetics
Potassium and magnesium aspartates are intensively absorbed in the intestine, mainly in the small intestine. Excreted by the kidneys.
Indications for use Panangin forte 60 pcs. film-coated tablets
To eliminate potassium and magnesium deficiency as part of combination therapy for various manifestations of coronary heart disease (including acute myocardial infarction); chronic heart failure; heart rhythm disturbances (including arrhythmias caused by an overdose of cardiac glycosides).
Contraindications
Hypersensitivity to any of the constituent components of the drug, acute and chronic renal failure, hyperkalemia, hypermagnesemia, Addison's disease, atrioventricular block I-III degree, shock (including cardiogenic) (blood pressure less than 90 mm Hg), metabolic disorders amino acids, myasthenia gravis, hemolysis, acute metabolic acidosis, dehydration state, age under 18 years (efficacy and safety have not been established). Pregnancy (especially in the first trimester of pregnancy) and the period of breastfeeding.
Application of Panangin forte 60 pcs. film-coated tablets during pregnancy and breastfeeding
Use is possible if the potential benefit to the mother outweighs the possible risk to the fetus.
Potassium and magnesium aspartate pass into breast milk. If it is necessary to take the drug during breastfeeding, breastfeeding should be stopped.
special instructions
Patients with diseases accompanied by hyperkalemia require special attention: regular monitoring of potassium levels in the blood plasma is necessary.
Overdose
The risk of symptoms of hyperkalemia and hypermagnesemia increases.
Symptoms of hyperkalemia: increased fatigue, myasthenia gravis, paresthesia, confusion, cardiac arrhythmia (bradycardia, atrioventricular block, arrhythmias, cardiac arrest).
Symptoms of hypermagnesemia: decreased neuromuscular excitability, nausea, vomiting, lethargy, decreased blood pressure.
With a sharp increase in the content of magnesium ions in the blood: inhibition of deep tendon reflexes, respiratory paralysis, coma.
Treatment: symptomatic therapy - intravenous administration of calcium chloride at a dose of 100 mg/min, if necessary - hemodialysis.
Side effects Panangin forte 60 pcs. film-coated tablets
Possible nausea, vomiting, diarrhea, discomfort or burning sensation in the epigastric region (in patients with anacid gastritis or cholecystitis), atrioventricular block, paradoxical reaction (increased number of extrasystoles), hyperkalemia (nausea, vomiting, diarrhea, paresthesia), hypermagnesemia (redness of the face , feeling of thirst, decreased blood pressure, hyporeflexia, respiratory depression, convulsions).
If any of the side effects listed become serious, or you notice side effects not listed in this leaflet, you should consult your doctor.
Drug interactions
Pharmacodynamic interaction
When used together with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, angiotensin-converting enzyme (ACE) inhibitors, and non-steroidal anti-inflammatory drugs, the risk of developing hyperkalemia up to the development of arrhythmia and asystole increases. The simultaneous use of potassium supplements with glucocorticosteroids eliminates the hypokalemia caused by the latter. Potassium reduces the undesirable effects of cardiac glycosides. Panangin Forte enhances the negative dromo- and bathmotropic effects of antiarrhythmic drugs. Magnesium reduces the effects of neomycin, polymyxin B, tetracycline and streptomycin. Anesthetics increase the inhibitory effect of magnesium preparations on the central nervous system; when used simultaneously with atracuronium, decamethonium, succinyl chloride and suxamethonium, neuromuscular blockade may be enhanced. Calcitriol increases the content of magnesium in the blood plasma, calcium supplements reduce the effects of magnesium supplements.
Pharmacokinetic interaction
Medicines that have an astringent and enveloping effect reduce the absorption of magnesium aspartate and potassium aspartate in the gastrointestinal tract, therefore it is necessary to maintain a three-hour interval between oral administration of Panangin Forte with the above medications.
Review from a cardiologist with 10 years of experience
Good day everyone. I am a cardiologist with 10 years of experience, Yulia Mikhailovna Istrakova. I want to share with the multimillion-dollar Internet audience about the high-quality drug “Panangin”, whose healing effect really deserves attention.
For many years now, my patients have been taking this modern medicine against heart pain, palpitations, ventricular tachycardia and other things, and strangely enough, this remedy helps them cope with illnesses and many heart diseases that have repeatedly tormented them for many years or even the whole life.
As a proven cardiologist, I try to recommend that many of my patients take the drug "Panangin" one or two tablets 3 times a day. In case of an advanced form of the disease, it is advisable to take one course of tablets, and then take a short break (3-4 months) and repeat again.
Review of the medicinal properties of the drug
Our busy life can make us worry, nervous, depressed, and feel anxious and in danger.
When the heart cannot withstand such stress, it begins to send signals in the form of pain , sharp shocks and try to force us to influence the current circumstances, find ways to solve the problem by taking a remedy that helps reduce the pain defect and, ultimately, gain the long-awaited victory over it. victory.
Sometimes this can be done quickly, and sometimes there are times when no pills help cure yourself of an illness. Pain in the heart, like an “uninvited” guest, begins to arise again and again.
Panangin is a medicine that contains potassium and magnesium. These chemicals improve the cardiovascular system, thereby reducing the risk of arrhythmia and are active fighters in the treatment of this disease, and also prevent the formation of blood clots, improve myocardial function, regulate metabolic processes in the heart muscle, support the walls of blood vessels, and reduce the risk of premature aging, hypertension, atherosclerosis and much more.
Thanks to this drug, many of my patients have been successfully treating heart pain and cardiovascular diseases for many years. And all because they use this fairly affordable medicine, replenishing the deficiency of potassium and magnesium in their body. And the result is really pleasing!
Useful facts about the drug from a specialist
Today Panangin is a very popular drug, since its cost is acceptable even for the average person of retirement age. Of course, like any other medicine, this drug has its contraindications for use and side effects prescribed in the instructions.
The storage conditions and periods of the medicine are always indicated on the packaging. Self-treatment is contraindicated: to avoid harming your body, consult your doctor!
Review by Stanislav Nikolaevich, cardiologist
Many patients believe that Panangin is ordinary vitamins that can be taken without fear for their health. Actually this is not true. Improper use of the medication can lead to severe metabolic disorders and disruption of the heart.
I recommend using the product only with a doctor's prescription in accordance with the instructions.
